Don’t Stop GLP-ing

Hey readers, looks like we sent out yesterday’s edition with the Loose Nuts section missing. Here’s that story (plus a few headlines) for you. Happy Thanksgiving & see you next week!

Don’t Stop GLP-ing

• GLP-1 weight loss jabs like Ozempic and Mounjaro have taken the world by storm. According to new data, roughly 12% of U.S. adults are currently using the drugs. In case you forgot, GLP-1 jabs are helpful in a wide range of cases including treating diabetes, lowering weight, reducing blood pressure, and lowering levels of “bad” cholesterol — they do this by mimicking your body’s GLP-1 hormone, which regulates blood sugar and appetite. But what happens when you stop using them?

• Past research has shown that, when someone stops using GLP-1s, any weight they might have lost due to the drug returns rapidly. A new study shows that the blowback doesn’t stop there – other benefits like lowered blood pressure and reduced “bad” cholesterol levels also snap back to pre-GLP levels when people stop using the jab.

• “The findings are not a surprise, as excess weight is a well-established driver of elevated blood pressure and impaired glucose control,” said one professor of cardiometabolic medicine not associated with the study. “Consequently, when weight lost through therapeutic interventions is regained, these cardiometabolic risk factors typically rise in proportion to the speed and extent of weight regain,” he added. So 12% of the U.S. is essentially stuck using these drugs for the rest of their lives if they want to keep their health stable.

Additional Reads

• Signs of Fatigue: Trump Faces Realities of Aging in Office (NYT, $)

• Ukraine says 'understanding' reached with US on peace plan, as Trump says his envoy will meet Putin in Moscow (BBC)

• Chatbots Are Becoming Really, Really Good Criminals (Atlantic, $)

• Is ChatGPT Conscious? (NYMag)

• Connecticut DMV Fires Employee Who Made Thousands Selling Towed Cars (ProPublica)

• Campbell’s Soup executive called its products food for ‘poor people’, lawsuit alleges (Guardian)

• Ex-President Bolsonaro starts serving 27-year sentence for Brazil coup plot (Reuters)

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